We depend on our members to fund our Fort Worth and Tarrant County business reporting. All the results were analyzed with NanoScope Analysis V.1.5 (Bruker). The scan area was 2 × 2 m2, the scan rate was 1 Hz, and the images consisted of 256 lines, in the AFM measurements.

It has spun off several companies Nanoscope Therapeutics Inc, Nanoscope Instruments Inc, Nanoscope Diagnostics LLC and Opsin Biotherapeutics Inc for commercialization of the platform technologies. Atomic force microscopy (AFM- Bruker EDGE 3-SYS) was used for 3D topography of the surface as well as roughness and bearing analysis. Nanoscope Technologies, LLC, founded in 2009 by Samarendra Mohanty, PhD., has received several SBIR awards, National Institutes of Health (NIH) R01 grants, and patents which focus on optical stimulation, gene delivery, and imaging for neural activity monitoring. The development of a safe, effective, long-lasting single dose therapeutic for the treatment of POAG would improve the lives of millions of people suffering from this devastating disease. Therefore, Nanoscope’s approach of correcting the pathological phenotype rather than correction of genetic mutation in a gene-independent manner would be transformative in clinical ophthalmology. POAG is heterogenous, and known to be caused by different genetic mutations, however, most contributing mutations are still unknown. Use of EMC in the impaired TM of glaucomatous eyes as an autonomous pressure modulator is novel and has significant promise for Glaucoma”, said Samarendra Mohanty, President and Chief Scientific Officer. “EMC is an engineered version of a stretch-activated channel, which directly senses tension in the membrane lipid bilayer of cells and in response, transiently opens its pore for fluid exchange. Using patented gene-agnostic EMC therapy, Nanoscope researchers have demonstrated that lowering of the intraocular pressure (IOP) in animal models of glaucoma. EMC acts as an ideal drainage valve for trabecular meshwork (TM), because it is a relatively small homo-oligomeric channel and does not need any associated proteins or energy sources to assemble and function.

Nanoscope analysis 1.5 download